Severe Maternal Mental Disoders and Adverse Perinatal Outcomes: A Cross-Jursdicational Population Data Linkage study in Australia

Abstract

Objective
To examine the association between severe maternal mental disorders and adverse perinatal outcomes using population-based linked data from Western Australia (WA) and New South Wales (NSW), Australia.

Approach
We conducted a population-based retrospective cohort study using perinatal datasets from WA and NSW, including births (n=1.76 million) between 1995 and 2015. Maternal mental health disorders (exposure) were identified using ICD-10-AM diagnosis codes if a primary or additional diagnosis was recorded within one year preceding the index birth. Outcomes evaluated included preterm birth, small for gestational age (SGA), low birth weight (LBW), and perinatal death. A generalised linear model with log link (binomial or Poisson) was employed to examine the associations.

Results
The analysed included 3,817 births exposed to severe maternal mental disorders within one year before birth. After adjusting for a range of potential confounders, pregnancies exposed to severe maternal mental disorders in the one year before the birth were associated with increased risks of preterm birth with risk ratios and 95% CI of 1.82 (1.69, 1.97), low birth weight 1.74 (1.60, 1.89), small for gestational age 1.11 (1.03, 1.20) and perinatal death 1.53 (1.17, 2.02). Similar but elevated risk association patterns were observed across severe maternal mental disorder categories, including schizophrenia, bipolar disorder, and substance-induced psychotic disorders and adverse perinatal outcomes.

Conclusions and implication
Severe maternal mental disorders pre-pregnancy are associated with increased risk of multiple adverse perinatal outcomes. Linked population data provide critical evidence to inform preconception and perinatal care strategies for women with severe mental illness.