Algorithmic Identification of Multiple Sclerosis  in the SAIL databank

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Rod Middleton
Richard Nicholas
Emma Tallantyre
James Witts
Ruth Ann Marrie
Elaine Craig
Sarah Knowles
Owen Pearson
Katherine Harding
Karim Kreft
Jonathon Hawken
Gillian Ingram
Bethan Morgan
Neil Robertson

Abstract

Background
Multiple Sclerosis (MS) is a challenging disease to identify within large repositories of healthcare data. Diagnosis can be protracted requiring many modalities that may not form part of the repository data collection. Accurate case finding would have multiple applications for studying epidemiology.


Aim
Develop a case finding algorithm within the Secure Anonymised Information Linkage (SAIL) Databank that can reliably elicit Multiple Sclerosis.


Method
Utilising a cross sectional cohort study we used multiple datasets within SAIL; General Practice, Inpatient, Outpatient and Office of National Statistics to develop our case finding algorithm based on the coding nomenclatures and timing within these datasets. The results of this algorithm were then tested against two patient data sets: The UK MS Register (n=836), consisting of mostly self confirmed disease and a clinical cohort from South West Wales (n=713).


Results
From 4,757,428 records, the algorithm identified 6,194 cases of MS within Wales on 31st December 2020 (prevalence 221.65 [95%CI 216.17–227.24] per 100,000). Case finding sensitivity and specificity was 96.8% and 99.9% for the clinically validated population-based cohort and sensitivity was 96.7% from the self-declared registry population.


Conclusion
We successfully identified MS cases within Wales and verified this within two independent data sets.

Article Details

How to Cite
Middleton, R., Nicholas, R., Tallantyre, E., Witts, J., Marrie, R. A., Craig, E., Knowles, S., Pearson, O., Harding, K., Kreft, K., Hawken, J., Ingram, G., Morgan, B. and Robertson, N. (2024) “Algorithmic Identification of Multiple Sclerosis  in the SAIL databank”, International Journal of Population Data Science, 9(5). doi: 10.23889/ijpds.v9i5.2537.

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